474 research outputs found
Infrared Instrumentation and Astronomy
Contains reports on five research projects.Joint Services Electronics Program (Contract DAAB07-76-C-1400)National Aeronautics and Space Administration (Grant NGR 22-009-526)National Aeronautics and Space Administration (Grant NSG-7328)National Aeronautics and Space Administration (Contract NAS5-24096
Renormalized spin coefficients in the accumulated orbital phase for unequal mass black hole binaries
We analyze galactic black hole mergers and their emitted gravitational waves.
Such mergers have typically unequal masses with mass ratio of the order 1/10.
The emitted gravitational waves carry the inprint of spins and mass quadrupoles
of the binary components. Among these contributions, we consider here the
quasi-precessional evolution of the spins. A method of taking into account
these third post-Newtonian (3PN) effects by renormalizing (redefining) the 1.5
PN and 2PN accurate spin contributions to the accumulated orbital phase is
developed.Comment: 10 pages, to appear in Class. Quantum Grav. GWDAW13 Proceedings
Special Issue, v2: no typos conjectur
Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5âČ-phosphate synthesis
Overexpression of seven different genes restores growth of a ÎpdxB strain of E. coli, which cannot make pyridoxal phosphate (PLP), on M9/glucose.None of the enzymes encoded by these genes has a promiscuous 4-phosphoerythronate dehydrogenase activity that can replace the activity of PdxB.Overexpression of these genes restores PLP synthesis by three different serendipitous pathways that feed into the normal PLP synthesis pathway downstream of the blocked step.Reactions in one of these pathways are catalyzed by low-level activities of enzymes of unknown function and a promiscuous activity of an enzyme that normally has a role in another pathway; one reaction appears to be non-enzymatic
Adaptive Event Horizon Tracking and Critical Phenomena in Binary Black Hole Coalescence
This work establishes critical phenomena in the topological transition of
black hole coalescence. We describe and validate a computational front tracking
event horizon solver, developed for generic studies of the black hole
coalescence problem. We then apply this to the Kastor - Traschen axisymmetric
analytic solution of the extremal Maxwell - Einstein black hole merger with
cosmological constant. The surprising result of this computational analysis is
a power law scaling of the minimal throat proportional to time. The minimal
throat connecting the two holes obeys this power law during a short time
immediately at the beginning of merger. We also confirm the behavior
analytically. Thus, at least in one axisymmetric situation a critical
phenomenon exists. We give arguments for a broader universality class than the
restricted requirements of the Kastor - Traschen solution.Comment: 13 pages, 20 figures Corrected labels on figures 17 through 20.
Corrected typos in references. Added some comment
Seismic isolation of Advanced LIGO: Review of strategy, instrumentation and performance
The new generation of gravitational waves detectors require unprecedented levels of isolation from seismic noise. This article reviews the seismic isolation strategy and instrumentation developed for the Advanced LIGO observatories. It summarizes over a decade of research on active inertial isolation and shows the performance recently achieved at the Advanced LIGO observatories. The paper emphasizes the scientific and technical challenges of this endeavor and how they have been addressed. An overview of the isolation strategy is given. It combines multiple layers of passive and active inertial isolation to provide suitable rejection of seismic noise at all frequencies. A detailed presentation of the three active platforms that have been developed is given. They are the hydraulic pre-isolator, the single-stage internal isolator and the two-stage internal isolator. The architecture, instrumentation, control scheme and isolation results are presented for each of the three systems. Results show that the seismic isolation sub-system meets Advanced LIGO's stringent requirements and robustly supports the operation of the two detectors.Laser Interferometer Gravitational-Wave ObservatoryNational Science Foundation (U.S.
An overview of the PubChem BioAssay resource
The PubChem BioAssay database (http://pubchem.ncbi.nlm.nih.gov) is a public repository for biological activities of small molecules and small interfering RNAs (siRNAs) hosted by the US National Institutes of Health (NIH). It archives experimental descriptions of assays and biological test results and makes the information freely accessible to the public. A PubChem BioAssay data entry includes an assay description, a summary and detailed test results. Each assay record is linked to the molecular target, whenever possible, and is cross-referenced to other National Center for Biotechnology Information (NCBI) database records. âRelated BioAssaysâ are identified by examining the assay target relationship and activity profile of commonly tested compounds. A key goal of PubChem BioAssay is to make the biological activity information easily accessible through the NCBI information retrieval system-Entrez, and various web-based PubChem services. An integrated suite of data analysis tools are available to optimize the utility of the chemical structure and biological activity information within PubChem, enabling researchers to aggregate, compare and analyze biological test results contributed by multiple organizations. In this work, we describe the PubChem BioAssay database, including data model, bioassay deposition and utilities that PubChem provides for searching, downloading and analyzing the biological activity information contained therein
TACI-Ig Neutralizes Molecules Critical for B Cell Development and Autoimmune Disease Impaired B Cell Maturation in Mice Lacking BLyS
AbstractBLyS and APRIL have similar but distinct biological roles, mediated through two known TNF receptor family members, TACI and BCMA. We show that mice treated with TACI-Ig and TACI-Ig transgenic mice have fewer transitional T2 and mature B cells and reduced levels of circulating immunoglobulin. TACI-Ig treatment inhibits both the production of collagen-specific Abs and the progression of disease in a mouse model of rheumatoid arthritis. In BLyS-deficient mice, B cell development is blocked at the transitional T1 stage such that virtually no mature B cells are present, while B-1 cell numbers are relatively normal. These findings further elucidate the roles of BLyS and APRIL in modulating B cell development and suggest that BLyS is required for the development of most but not all mature B cell populations found in the periphery
Testing gravitational-wave searches with numerical relativity waveforms: Results from the first Numerical INJection Analysis (NINJA) project
The Numerical INJection Analysis (NINJA) project is a collaborative effort
between members of the numerical relativity and gravitational-wave data
analysis communities. The purpose of NINJA is to study the sensitivity of
existing gravitational-wave search algorithms using numerically generated
waveforms and to foster closer collaboration between the numerical relativity
and data analysis communities. We describe the results of the first NINJA
analysis which focused on gravitational waveforms from binary black hole
coalescence. Ten numerical relativity groups contributed numerical data which
were used to generate a set of gravitational-wave signals. These signals were
injected into a simulated data set, designed to mimic the response of the
Initial LIGO and Virgo gravitational-wave detectors. Nine groups analysed this
data using search and parameter-estimation pipelines. Matched filter
algorithms, un-modelled-burst searches and Bayesian parameter-estimation and
model-selection algorithms were applied to the data. We report the efficiency
of these search methods in detecting the numerical waveforms and measuring
their parameters. We describe preliminary comparisons between the different
search methods and suggest improvements for future NINJA analyses.Comment: 56 pages, 25 figures; various clarifications; accepted to CQ
- âŠ